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Autoimmune kidney disease

Abstract. The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft. Whether all forms of glomerulonephritis should be considered as autoimmune disease is debatable, but immune. Learn about IgA nephropathy, or autoimmune kidney disease, which causes damage to the kidneys through the abnormal buildup of a protein The immune system is involved in many types of renal disease, but there is no universally accepted definition of the term autoimmune kidney disease. The most common cause of kidney failure worldwide today is diabetes mellitus, and at least for type I diabetes the origin is considered to be autoimmune

Autoimmune kidney diseases - PubMe

Autoimmune-disease related kidney disease. Certain autoimmune diseases such as lupus or rheumatoid arthritis, cause the immune system to attack the body's own cells. When this process affects the.. Chronic kidney disease (CKD) is the slow, gradual loss of kidney function. Some forms of CKD can be controlled or slowed down. For example, diabetic nephropathy can be delayed by tightly controlling blood glucose levels and using ACE inhibitors and ARBs to reduce proteinuria and control blood pressure Autosomal recessive polycystic kidney disease (ARPKD) Autosomal recessive PKD (ARPKD) is a much less common form of PKD. ARPKD causes cysts to form in both the kidneys and the liver. Symptoms of the disease can begin even before birth and can cause life-threatening problems in infants

IgA Nephropathy Autoimmune Kidney Diseas

Autoimmune kidney diseases - ScienceDirec

Other autoimmune diseases with renal manifestations . In a similar fashion discussed previously where autoimmune diseases cause pulmonary disease, the same scenario is seen with autoimmune disease and renal involvement. Rheumatoid arthritis, anti-phospholipid antibody syndrome, scleroderma and Sjögren's syndrome all have known renal complications Autoimmune disease: in autoimmune diseases, the body's immune system mistakenly attacks and damages its own tissue and organs, including the kidneys. Sometimes an autoimmune disorder such as systemic lupus erythematosus or Goodpasture's syndrome can lead to glomerular disease and affect the kidneys Aurinia Pharmaceuticals has bought two new pipeline assets to boost its rare autoimmune and kidney-related disease portfolio. These pipeline assets are AUR200 and AUR300 Aurinia paid an upfront $750,000 to stakeholders of private firm Thunderbolt Pharma for the acquisition. Aurinia secured rights to. Autoimmune Kidney Disease Clinic In autoimmune diseases, the immune system attacks part of the body as though it were an invader, like a virus. This can be especially serious if the attack involves the kidneys. At Seattle Children's Autoimmune Kidney Disease Clinic, we treat the whole patient, not just their kidneys or their disease

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Aurinia Acquires Novel Pipeline Assets Targeting Autoimmune and Kidney-related Diseases. Assets expand immunology portfolio to include B-cell therapy and macrophage modulation - - IND-enabling. Rare Daily Staff Aurinia Pharmaceuticals said it acquired two novel assets that will expand the company's rare autoimmune and kidney-related disease pipeline. Over the past year, in anticipation of building out and diversifying our development pipeline, we have brought on additional large and small molecule expertise that uniquely aligns with Aurinia's focus on immunology an Accumulating data suggest that a growing number of renal diseases result from autoimmune injury — including lupus nephritis, IgA nephropathy, anti-neutrophil cytoplasmic antibody-associated. Called autoimmune disease, these attacks can affect any part of the body, weakening bodily function and even turning life-threatening. Scientists know about more than 80 autoimmune diseases. Some are well known, such as type 1 diabetes, multiple sclerosis, lupus, and rheumatoid arthritis, while others are rare and difficult to diagnose

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Glomerulonephritis or Autoimmune Kidney Disease Signs and

  1. Because kidney symptoms show up frequently with autoimmune disorders I want to share some of those with you. Glomerulonephritis This is a glomerular disease. Remember the glomerular are the filtration units inside of the kidney. This disease is related to inflammation inside of the glomerular in the kidney
  2. Victoria-based Aurinia Acquires Novel Pipeline Assets Targeting Autoimmune and Kidney-related Diseases. Victoria, BC, August 18, 2021--Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) announced the addition of two novel assets that will expand the Company's rare autoimmune and kidney-related disease pipeline
  3. Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two novel assets that will expand the Company's rare autoimmune and kidney-related disease pipeline. Over the past year, in anticipation of building out and diversifying our development pipeline.

Video: Systemic autoimmune diseases and the kidne

Autoimmune disease was associated with lower odds of CVD (odds ratio [OR] 0.61 [95% confidence interval 0.37-1.00 for thyroid autoimmune disease] and OR 0.34 (95% CI 0.12-0.93) for non-thyroid. Autoimmune renal diseases represent a relevant source of morbidity and mortality in human beings [1]. They include several conditions with different clinical expressions, at the basis of which. Since its inception, Kidney International has published seminal articles describing the effects of systemic autoimmune diseases on the kidney. These manuscripts have characterized the pathology and clinical course of these diseases and perhaps most importantly have provided guidance to the nephrology community about how to treat these complex conditions using the best possible evidence. Autoimmune Kidney Disease Healed Naturally I initially came to the Natural Medicine Clinic for a chronic neck problem that I was having and in talking to the staff at the Natural Medicine Clinic, they determined that they could help me with my nutritional problems that I was having Goodpasture syndrome is a rare autoimmune disease that affects the lungs and kidneys. Normally, the immune system makes antibodies to fight off germs. With Goodpasture syndrome, however, the immune system mistakenly makes antibodies that attack the lungs and kidneys

Lupus nephritis - Symptoms and causes - Mayo Clini

  1. Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis.Some use the term Goodpasture syndrome for the findings of glomerulonephritis and pulmonary hemorrhage and the term Goodpasture disease for those patients with glomerulonephritis.
  2. Glomerulonephritis is another type of autoimmune kidney disease that attacks the waste filtration function of the kidneys. Glomerulonephritis is diagnosed when damage to the glomerulus causes protein and blood to be lost in the urine. The disease often develops quickly, and kidney function can be lost within weeks (rapidly progressive.
  3. Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis, and kidney failure. It is thought to attack the alpha-3 subunit of type IV collagen, which has therefore been referred to as Goodpasture's antigen
  4. After securing its first FDA approval in January, Aurinia Pharmaceuticals is beefing up its autoimmune and kidney-related diseases pipeline with two preclinical assets

The role of the immune system in kidney diseas

Autoimmune interstitial lung, joint, and kidney disease is an autosomal dominant systemic autoimmune disorder characterized by interstitial lung disease, inflammatory arthritis, and immune complex-mediated renal disease. Laboratory studies show high-titer autoantibodies. Symptoms appear in the first 2 decades of life, but there is incomplete penetrance (summary by Watkin et al., 2015) Autoimmune Diseases Auto Immunity Auto Immunity . We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads Unfortunately for the patient, most autoimmune diseases are not curable but are certainly controllable. With targeted therapies, we are able to control - sending the disease into remission. During this period, some patients may not require specific medications and with regular monitoring their kidney function and overall health can be spared

Kidney Disease: Types, Symptoms, Causes and Treatment U

It's a double whammy if you are a BIPOC with autoimmune disease and fall ill with Covid-19. Blacks had a 2.7-fold increased risk of requiring hospitalization (1.98 for Hispanics) than whites. Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in. But, I'm living proof that you can reverse an autoimmune disease. And, I'm not the only proof we have. The reversal of Alzheimer's ( 1 ) , Type 2 Diabetes ( 2 , 3 ) , kidney disease ( 4 ) , and other inflammatory conditions have been reported in scientific journals

Autoimmune glomerulonephritis, where your body attacks your own kidneys, is a common manifestation of lupus. In a case series of 29 patients who were fasted for 60 hours and then just put on fruits and vegetables until they got better, described such remarkable recoveries that fasting, in their opinion, should be an essential part of. A family history of kidney disease African-American and other ethnic minorities Obesity Smoking Older age Having protein in the urine Having autoimmune diseases such as lupus. CHRONIC KIDNEY DISEASE COMPLICATIONS. Most people with CKD do not have symptoms until the kidney function is at least moderately to severely impaired

Named granulomatosis with polyangiitis or wegeners disease the diagnosis causes inflammation of the blood vessels that can cause damage to. Aurinia Acquires Novel Pipeline Assets Targeting Autoimmune and Kidney-related Diseases. Assets expand immunology portfolio to include B-cell therapy (BAFF/APRIL) and macrophage modulation. IND-enabling studies are ongoing and will support the transition of these assets to clinical development in 2022/2023 Some nephrological diseases are likewise of autoimmunological etiology, one example being systemic lupus erythematosus (SLE), a chronic, mostly relapsing-remitting inflammatory disease with life-threatening courses in some cases. Manifestations occur on the skin and in organs such as the lungs, heart, CNS, muscles/joints - and the kidneys Both of these programs are rooted in strong science and at the leading edge of approaches for the treatment of autoimmune, fibrotic, and kidney diseases, said Rob Huizinga, PhD, RN, CNeph(C), Executive Vice President of Research, Aurinia. Significant research has been done to date in both BAFF/APRIL inhibition and macrophage modulation.

The team also used RELI to compare the genetic regions tied to risk of other autoimmune diseases. They found that EBNA2 bound to regions associated with the risk for multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis, and celiac disease Some nephrological diseases are likewise of autoimmunological etiology, one example being systemic lupus erythematosus (SLE), a chronic, mostly relapsing-remitting inflammatory disease with life-threatening courses in some cases. Manifestations occur on the skin and in organs such as the lungs, heart, CNS, muscles/joints—and the kidneys GN represents a heterogeneous group of renal autoimmune diseases that are characterized by a pathogenic immune response against renal autoantigens or by manifestations of systemic autoimmunity in the kidney . GNs are a major cause of chronic kidney diseases, accounting for about 10% of all patients on dialysis

Lupus nephritis (nef-RYE-tis) is the medical name for kidney swelling and irritation that is caused by lupus. Lupus is an autoimmune disease. Autoimmune diseases cause your immune system to attack your own healthy cells. When your immune system attacks your kidneys, they get damaged. The damage can be very serious Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two novel assets that will expand the Company’s rare autoimmune and kidney-related disease pipeline. Over the past year, in anticipation of building out and diversifying our. VICTORIA, British Columbia — Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two novel assets that will expand the Company's rare autoimmune and kidney-related disease pipeline. Over the past year, in anticipation of building out and diversifying our development pipeline, we have brought on additional large and small molecule. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. Symptoms vary in severity and age of onset, but usually develop between the ages of 30 and 40. ADPKD is a progressive disease and symptoms tend to get worse over time Aurinia acquires two pipeline assets targeting autoimmune and kidney diseases. Share. Flip. Like. Seeking Alpha - Mamta Mayani, SA News Editor • 2h. • Aurinia Pharmaceuticals (NASDAQ:AUPH) has added two novel assets that will expand its rare autoimmune and kidney-related disease pipeline. • First

Glomerular Diseases NIDD

The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation Do NOT follow this link! August 17, 2021 - 6:05 am. Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two novel assets that will expand the Company's rare autoimmune and kidney-related disease pipeline. Over the past year, in anticipation of building out and diversifying our development pipeline, we have brought on additional large and. The term Autoimmune Disease is used to describe conditions in which the body's immune system - which is supposed to be defending the body against viruses, bacteria and other invaders - is thought to be involved in causing or perpetuating illness. It's as if the body's defense system has turned on its host

Hepatitis treatment in patients with kidney disease: World Hepatitis Day is celebrated on 28th July every year to create awareness about Hepatitis. Although Hepatitis affects the liver, it can. Autoimmune diseases can affect several organs, such as the central nervous system (CNS) in multiple sclerosis (MS), the intestine in inflammatory bowel disease (IBD), the joints in rheumatoid arthritis, and the kidneys in glomerulonephritis The term autoimmune disease covers a broad variety of disorders in dogs that affect the immune system. A dog's immune system is a network of white blood cells, antibodies, and other. Diagnosed in 1991 with a rare autoimmune disease, Mundy became a patient at IU Health last year when her kidneys began to fail. Named Granulomatosis with polyangiitis or Wegener's Disease, the diagnosis causes inflammation of the blood vessels that can cause damage to walls of the arteries and veins. The damage interferes with normal blood.

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The kidney is also the target of autoantibodies that attack specific cell types in the glomerulus. These include membranous nephropathy and glomerular basement membrane nephropathy. Besides these established autoimmune diseases, acute kidney injury and chronic kidney disease have autoimmune features and are increasingly being considered to have. Lupus nephritis is inflammation of the kidney that is caused by systemic lupus erythematous (SLE). Also called lupus, SLE is an autoimmune disease.With lupus, the body's immune system targets its.

A better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. Despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or ANCA-associated vasculitis. Nonetheless the initial step leading to the formation of these antibodies is still obscure Glomerulonephritis is the most common form of primary kidney disease with a predominant lesion of the renal glomeruli. Currently, the concept of the immunoinflammatory genesis of this disease is generally recognized. Glomerulonephritis is the result of an inflammatory response to antigens, leading to tissue damage Autoimmune renal diseases include lupus nephritis, Goodpasture syndrome or anti-GBM (glomerular basement membrane) disease, ANCA-associated vasculitis, and other rare diseases. They are largely defined by the kidney sub-location affected by the autoantibodies or immune cells Autoimmune Disease Basics . Autoimmune disease happens when the body's natural defense system can't tell the difference between your own cells and foreign cells, causing the body to mistakenly attack normal cells. There are more than 80 types of autoimmune diseases that affect a wide range of body parts

The Leather pulse indicates severe deficiency of Blood, Essence or Yin. It also indicates Qi floating upwards because it is not rooted by Blood. This would indicate that the root of these autoimmune diseases is a Kidney deficiency. APPROACH TO TREATMENT OF AUTO-IMMUNE DISEASES - No Chinese theory obviously Another key factor that can play a role in autoimmune disease is infections. Research has linked a number of viral and bacterial infections to autoimmune disease, including Epstein-Barr (the virus that causes mono), Herpes Simplex 1 and 2, E. coli, and more Lab diagnosis autoimmune disease 1. Guide: Dr.(Mrs.)M.V.Jadhav 2. This topic will be covered under the following heads. 1. Concepts of autoimmune diseases 2. Theories of autoimmune diseases 3. Introduction 4. Spectrum of autoimmune diseases 5. Historical events 6. Indications 7. Lab work up for autoimmune diseases 8

Chronic kidney disease (CKD) is a major public health concern that affects approximately 47 million persons in the United States, or 14.8% of the U.S. adult population.1 It is associated with. VICTORIA, British Columbia - (COMMERCIAL THREAD) - Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two new assets that will expand the Company's portfolio of rare autoimmune and kidney diseases.COMMERCIAL THREAD) - Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) toda People with lupus develop autoimmune antibodies that can attach to tissues throughout the body. The joints, lungs , blood cells , nerves, and kidneys are commonly affected in lupus

Current treatment of autoimmune kidney diseases and nephrotic syndromes, including SLE and FSGS, relies on the use of systemic administration of corticosteroids and cytotoxic drugs, which can cause unwanted side effects. The development of drugs that target molecules involved in the pathogenesis of disease is qualified by the fact that these. According to Medline Plus, acute nephritic syndrome is an autoimmune disease that causes inflammation of the kidneys 2. This is another condition that typically results from other ailments. The kidney swelling that occurs in those that suffer from acute nephritic syndrome causes damage to the section of the kidneys that filters waste CD4+ T cells are key drivers of autoimmune diseases, including crescentic GN. Many effector mechanisms employed by T cells to mediate renal damage and repair, such as local cytokine production, depend on their presence at the site of inflammation. Therefore, the mechanisms regulating the renal CD4+ T cell infiltrate are of central importance. From a conceptual point of view, there are four.

Rare diseases - less common diseases can cause kidney

Autoimmune diseases are on the rise in a significant way. Worldwide, up to 700 million people are estimated to be suffering from autoimmune disorders right now. And in the U.S., autoimmune diseases are the third most common category of illness, after cancer and heart disease. About 78% of autoimmune disease cases take place in women ANCA vasculitis is a type of autoimmune disease that causes vasculitis. ANCA stands for Anti-Neutrophilic Cytoplasmic Autoantibody. All of these terms will be explained here, including how the disease works and what we can do for it. You may hear different names or terms for this disease, including ANCA vasculitis, ANCA disease, ANCA-associated vasculitis. Other Continue Autoimmune diseases occur when the immune system wrongly attacks the body's own cells. In these cases, the immune system thinks that healthy cells within the body are actually foreign cells. Thus, it can destroy parts of the body that are important to health. Some examples of autoimmune diseases are: Type 1 diabetes GBM) disease is the best-defined renal organ-specific autoimmune disease. The disease is strongly associated with autoantibody formation to a specific target found in the glomerular and alveolar basement membranes, and is characterized by a rapidly progressive glomerulonephritis (RPGN) which is often associated with pulmonary hemorrhage, thoug Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced the addition of two novel assets that will expand the Company's rare autoimmune and kidney-related disease.

Aurinia acquires pipeline assets for autoimmune and kidney

Autoimmune diseases cause the body to produce antibodies that attack its own tissues, leading to deterioration, and in some cases destruction, of tissue.Many autoimmune diseases that carry a higher risk to the patient's health are defined in ICD-10 nomenclature, but codes are not narrowed down to o Autoimmune kidney diseases. Segelmark, Mårten LU and Hellmark, Thomas LU () In Autoimmunity Reviews 9. p.366-371. Mark; Abstract The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft Kidney disease can be caused by inflammation of the filters inside the kidneys, known as glomerulonephritis. In some cases this happens as a result of the immune system mistakenly attacking the kidneys. If a kidney biopsy finds this is the cause of your kidney problems,.

Aurinia Pharmaceuticals (NASDAQ:AUPH) has added two novel assets that will expand its rare autoimmune and kidney-related disease pipeline.; First program, AUR200, was acquired by purchasing all of. Kidney disease can affect people of any age and any race or cultural background. However, a number of factors increase the risk of developing kidney disease. Risk factors include: Age older than 65 years. African American, Native American, Hispanic American, Asian, or Pacific Islander ethnicity. Diabetes. Exposure to radiographic contrast materia Low Dose Naltrexone (LDN) helps regulate the immune system, benefiting patients with a variety of autoimmune and related diseases. This page shows just a few of the conditions for which LDN use has been tested in clinical trial Types of Autoimmune Disease. Some common autoimmune conditions include: Hashimoto's Thyroiditis - the immune system attacks the thyroid, thereby decreasing its effectiveness, resulting in hypothyroid symptoms; Inflammatory Bowel Disease (IBD) - ulcerative colitis or Crohn's disease, whereby the immune system attacks the lining of the colon causing diarrhea, nausea, and abdominal pain

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Kidney Disease in Children NIDD

Stage 3 of chronic kidney disease (CKD) occurs when your estimated glomerular filtration rate (eGFR) falls between 30-59, indicating moderate kidney damage and noticeable loss of kidney function. This stage is separated into 2 sub-stages: stage 3a kidney disease with an eGFR of 45-59 and stage 3b with an eGFR of 30-44 Dysfunction of podocytes, cells critical for glomerular filtration, underlies proteinuria and kidney failure. Genetic forms of proteinuric kidney disease can be caused by mutations in several podocyte genes, including nephrin, a critical component of the kidney filter. In contrast, the etiology of acquired acute-onset nephrotic syndrome has remained elusive Kidney disease occurs when kidneys stop doing their regular functions. It could be the result of traumatic injury, inadequate blood flow, severe dehydration, pregnancy complications, sepsis, an enlarged prostate, urine backup, or an autoimmune disorder — which may cause waste products and toxins build up in your body

Goodpasture's Syndrome National Kidney Foundatio

If the autoimmune condition is really a disease of the target tissue, the rate of recurrence should be close to 0%, especially since the organs are screened to be disease-free before implantation. Polycystic kidney disease, for example, is truly a disease of the kidney and not a systemic disease, as there is zero incidence of recurrence post. Autoimmune disease never gets better - it only gets worse over time. Of course, severe autoimmune disease mandates the GAPS Diet as perhaps the only viable option for reversal and healing. For this reason, it may be worthwhile to consider the GAPS diet as a measure to fix gut dysbiosis once and for all Autoimmune Diseases and Kidney Failure Autoimmune diseases can affect almost any part of the body, including the heart, brain, nerves, muscles, skin, eyes, joints, lungs, kidneys, glands, the. Almost every autoimmune disease has more than one name. In some cases, the name is a simple synonym or abbreviation (lupus for systemic lupus erythematosus). In some, the alternative name is actually a subtype. A subtype is a more specific clinical definition of the main disease. These specific definitions can be used to identify patients. Idiopathic membranous nephropathy is an autoimmune kidney disease that leads to kidney failure in at least half of patients if left untreated. Immunosuppressive therapy is effective, but toxic.

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Chronic Kidney Disease And Autoimmune (Updated 2021

Autoimmune kidney disease can also be seen less commonly in other primary immunodeficiency diseases including CVID and APECED. Symptoms. In many cases, the first sign of autoimmune kidney disease is elevated blood pressure. This is often accompanied by the appearance of blood or protein in the urine Autoimmune kidney disease, inc luding. missionhospitals.org. missionhospitals.org. Enfermedad renal autoinmunitaria, como. missionhospitals.org. missionhospitals.org. The absence of systemic diseas e or autoimmune disease make s people with polycy stic kidney disease good candidates for kidney transplantation The team of experts in The Pediatric Nephrology Division at C.S. Mott Children s Hospital, comprehensively treats all children with medical diseases of the kidneys and lower urinary tract, fluid and electrolyte imbalances, acute kidney failure, and those with end-stage kidney disease who require treatment with either dialysis or transplantation

T cells and autoimmune kidney disease Nature Reviews

Kidney disease (also called renal disease) is a general term for when the kidneys are damaged and do not function as they should. If you have kidney disease that lasts for more than 3 months, it is called chronic kidney disease (or CKD). When the kidneys do not work properly, wastes and fluids build up inside the body

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